Please help disinfect my pc

I have no idea as to how to fix my pc. I feel as if i have been infected by multiple sources of malware. I am running Windows Vista 32 bit. Originally, it deleted my restore points and blocked access to folder options, taskmanager, and the registry. I managed to get the folder options, taskmanager, and registry back using RRT tools. However, it still wont let me run any anti malware/spyware software. I've tried installing and running malwarebytes, spybot, adaware, superantispyware, and hijackthis. I have to rename malwarebytes in order to install and run it. However, for all of the aforementioned software, they all close after 2-5 seconds of scanning and then i am forced to reinstall them because of an error where i no longer have permission to access the file. I ran CCleaner on the applications but not the registry. I've tried running all of this in safe mode and the same errors come up. I have tried to run it under a different user account but it also does not work. I am running out of ideas, please shed some light on this dilemma. Thanks.

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