Annoying Malware - Blank Desktop hard to remove

Malware has most likely infected my system, when Windows loads, most background program load successful, except my desktop & icons etc. In other words I have a blank windows desktop. I don't have a recent backup; I can't do a backup restore and even if I did, I believe I was living with this malware for weeks before running Malwarebytes which supposedly removed the malware but caused this problem as the same time. I've lost a week worth of work; I've been informed it's not serious; but it's hard to track down to retrieve my desktop back to normal, I believe it has taken over explorer.exe, why I can't run explorer.exe from the taskbar & until I can prevent it from hijacking windows explorer, it will be a pain in the butt to fix this.